Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.
ADVERSE REACTIONS
The presence of risk factors for overdose should not prevent the proper management of pain in any given patient. Also consider prescribing naloxone if the patient has household members (including children) or other close contacts at risk for accidental ingestion or overdose. If naloxone is prescribed, educate patients and caregivers on how to treat with naloxone. see Dosage and Administration (2.2), Warnings and Precautions (5.1, 5.3), Overdosage (10). Because extended-release products such as OXYCONTIN deliver the opioid over an extended period of time, there is a greater risk for overdose and death due to the larger amount of oxycodone present see Drug Abuse and Dependence (9). Life-Threatening Respiratory DepressionSerious, life-threatening, or fatal respiratory depression may occur with use of OXYCONTIN, especially during initiation or following a dosage increase.
Contraindications for Oxycontin
Therefore, a dosage reduction is recommended for these patients see DOSAGE AND ADMINISTRATION. Inform patients of the risk of life-threatening respiratory depression, including information that the risk is greatest when starting OXYCONTIN or when the dosage is increased, and that it can occur even at recommended dosages. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should take oxycodone while you are pregnant or trying to get pregnant. If you take oxycodone on a regular basis during pregnancy, your baby may have opioid withdrawal symptoms that can be life-threatening. Tell your health care provider if you took oxycodone during your pregnancy, especially near the end of your pregnancy.
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- Inform patients and caregivers not to increase opioid dosage without first consulting a clinician.
- Consider use of an alternative analgesic in patients who have difficulty swallowing and patients at risk for underlying GI disorders resulting in a small gastrointestinal lumen.
- Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.
- It is safer to underestimate a patient’s 24-hour oral oxycodone requirements and provide rescue medication (e.g., immediate-release opioid) than to overestimate the 24-hour oral oxycodone requirements and manage an adverse reaction due to an overdose.
Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you drug addiction and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer’s website to get the instructions.
- Dispose of unwanted capsules, tablets, extended-release tablets, extended-release capsules, and liquid properly according to instructions.
- OXYCONTIN, like other opioids, can be diverted for nonmedical use into illicit channels of distribution.
- This article helps you understand the differences and similarities between these two drugs and how they work.
Opioid use increases the risk of CSA in a dose-dependent fashion. In patients who present with CSA, consider decreasing the opioid dosage using best practices for opioid how addictive is oxycontin taper. Inform patients that use of opioids for an extended period of time may cause reduced fertility.
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Neonatal opioid withdrawal syndrome presents as irritability, hyperactivity and abnormal sleep pattern, high pitched cry, tremor, vomiting, diarrhea, and failure to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary based on the specific opioid used, duration of use, timing and amount of last maternal use, and rate of elimination of the drug by the newborn. Observe newborns for symptoms of neonatal opioid withdrawal syndrome and manage accordingly see Warnings and Precautions (5.4). Reserve concomitant prescribing of OXYCONTIN and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate see Warnings and Precautions (5.3), Drug Interactions (7).
Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient’s clinical status see Overdosage (10). Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids. OXYCONTIN may increase the risk of serious adverse reactions such as https://humboldtbargrill.thefush.com/factors-that-affect-how-quickly-you-feel-drunk/ those observed with other opioid analgesics, including respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, or shock see OVERDOSE.
- Accidental IngestionAccidental ingestion of even one dose of OXYCONTIN, especially by children, can result in a fatal overdose of oxycodone see Warnings and Precautions (5.2).
- Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby.
- Regularly evaluate patients, particularly when initiating and titrating OXYCONTIN and when OXYCONTIN is given concomitantly with other drugs that depress respiration see Warnings and Precautions (5.2, 5.3), Drug Interactions (7).
This medicine should not be used to treat pain that you only have once in a while or “as needed”. OXYCONTIN in healthy subjects in pharmacokinetic studies, steady-state levels were achieved within hours. If the response to an opioid antagonist is suboptimal or only brief in nature, administer additional antagonist as directed by the product’s prescribing information. Inform female patients of reproductive potential that OXYCONTIN can cause fetal harm and to inform their healthcare provider of a known or suspected pregnancy see Use In Specific Populations. Instruct patients how to recognize symptoms of low blood pressure and how to reduce the risk of serious consequences should hypotension occur (e.g., sit or lie down, carefully rise from a sitting or lying position) see WARNINGS AND PRECAUTIONS.